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Home | Intellectual Cores | Core Working Area
| FINLAND - Dr. Jussi Taipale |
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| Molecular methods |
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| Jussi Taipale, Biomedicum Helsinki, P.O.Box 63, FI-00014 University of Helsinki, FINLAND |
| Tel:+358 9 191 25677 |
| Fax:+358 9 191 25630 |
| Email: |
| Web:http://research.med.helsinki.fi/gsb/taipale/ |
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 The main strength of the group is in biochemistry and molecular biology or signal transduction and cancer. In particular, how aberrant activation of the Hedgehog and Wnt signaling pathways lead to tumorigenesis in skin and colon, respectively. The laboratory has special skills in the development and automation of microwell-plate based assays. For this project, Dr. Taipale has developed a novel automatable method for determination of the effect of all single base substitutions to the binding affinity of mammalian transcription factors.  Dr. Taipale is also directing the set-up of a high throughput center for Biomedicum Helsinki, which will allow somatic cell genetic analysis of 10 000- 40 000 samples using RNAi or cDNA expression. This resource will be available for the partners for screening of candidate genes using cell-based assays. |