Department of Biosciences at Novum, Huddinge, houses the Multifactorial Diseases Research Group directed by Professor Kere. The group has earlier coordinated or conducted clinical data and sample collections to support genetic mapping and positional cloning projects in the following complex phenotypes: asthma, dyslexia, psoriasis, pre-eclampsia, systemic lupus erythematosus and recurrent erysipelas infections. These projects have completed genome scans in all of the listed phenotypes, and so far, susceptibility genes have been identified in asthma, dyslexia and psoriasis.
Clinical Research Centre, Karolinska University Hospital, Huddinge, houses the Mutation Analysis core facility (MAF) directed by Professor Kere. MAF is equipped with high-throughput robotic setup of PCR assays, the Sequenom MALDI-TOF mass spectrometry SNP analysis platform, and a laboratory information management system (LIMS) with implemented quality control procedures to ensure data integrity. MAF provides genotyping services for researchers on the first come-first served, cost-recovery basis, following the principles set forth for the WCN core facilities. The current maximal throughput is approximately 10,000 SNP assays per working day, and MAF has since its opening in 2003 contributed to over 20 projects from KI, other Swedish universities, and international consortia.
Clinical Research Centre, Karolinska University Hospital, Huddinge, houses the Mutation Analysis core facility (MAF) directed by Professor Kere. MAF is equipped with high-throughput robotic setup of PCR assays, the Sequenom MALDI-TOF mass spectrometry SNP analysis platform, and a laboratory information management system (LIMS) with implemented quality control procedures to ensure data integrity. MAF provides genotyping services for researchers on the first come-first served, cost-recovery basis, following the principles set forth for the WCN core facilities. The current maximal throughput is approximately 10,000 SNP assays per working day, and MAF has since its opening in 2003 contributed to over 20 projects from KI, other Swedish universities, and international consortia.